Allergic to exercise?

Posted on Wednesday, July 16, 2008 3:32 PM PT
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By Melissa Dahl

Does all that exertion on the elliptical machine make you nauseous? Have you ever been convinced that if you spend even one more minute on the treadmill, you will actually die? Maybe it’s not all in your head.

A few people are actually allergic to exercise, and in very rare cases, a sweaty workout could be enough to kill them.


Exercise-induced anaphylaxis is a fairly rare condition which can cause hives, fainting, vomiting and difficulty breathing during a workout, and the symptoms can last up to four hours after it. In some cases, it can be triggered by certain foods eaten before exercise, like peanuts, shellfish, eggs or even, in two reported cases, celery. But this isn't just your average food allergy, an expert explains.

"These are people who will not have this reaction unless they exercise right after eating this food," says Dr. Jacqueline Eghrari-Sabet, an allergist in private practice in Montgomery Village, Md., and a spokeswoman for the American Academy of Allergy, Asthma and Immunology. "Eating shellfish and sitting there? Nothing. But eating shellfish and exercising? For these people, it's bad news."

As you exercise and your heart rate speeds up, your blood starts whizzing through organs much faster, and therefore more frequently, than it normally does. With every trip your blood takes to your stomach, it's picking up more, say, celery bits. For those with exercise-induced anaphylaxis, the normal amount of celery antigens picked up by the blood isn't enough to bother them. But while exercising, the extra celery bits their blood is picking up causes an allergic reaction.

Running and jogging are the most likely to trigger an attack, but other strenuous activities like dancing, volleyball, skiing and even yard work can also cause a reaction.

Since the 1970s, only 1,000 cases of exercise-induced anaphylaxis have been documented – and among those cases, one death. Experts believe that’s because many people with this condition are able to recognize the symptoms quickly and keep it under control by waiting a couple hours after they eat to work out and bookending their workouts with a slow warm-up and cool-down.

"It'll usually happen when you're really exercising," says Eghrari-Sabet. "I don't think you're going to get it when you're bowling. But if you're doing cardio or a hip hop class, then, yes."

Others suffer from the less serious exercise allergy cholinergic urticaria, a common type of heat rash, which differs from anaphylaxis in that it starts and ends with the skin reaction – no nausea or difficulty breathing for these folks. Ten to 20 percent of the population will experience some form of it during their lives. Besides exercise, sun exposure, spicy foods or even getting too emotionally worked up can cause an itch attack.

The condition can strike spontaneously, so even if you’ve been exercising all your life with nary a rash, you can unexpectedly break out in hives. Even some marathon runners have suddenly come down with a bad case of the itches after jogging, explains Eghrari-Sabet. Women are most susceptible to the condition, and the average age for its first appearance is 16. (A handy way to get out of gym class?)

Unfortunately for people seeking an excuse not to break a sweat, most dermatologists and allergists send their patients with exercise-related allergies right back to the locker room.

“If they come to me, I’m not going to tell them not to exercise,” says Dr. Bruce Robinson, a Manhattan dermatologist.  Instead he advises patients to pick a less strenuous regimen or a cooler place to work out.

Because the itchy sensation happens when body temperature suddenly rises, it can be eased by warming up and cooling down slowly, before and after every workout. Or try swimming for your normal cardio routine, which will keep the body temperature cool. If a food allergy is the culprit, don’t eat for a couple of hours before your workout.

Although serious side effects are rare, some experts believe, that exercise-induced anaphylaxis often goes undiagnosed. So if you start to feel itchy while working out, watch out. It’s probably best to avoid death by treadmill at all costs.

For more on exercise allergies and other workout quandries, read our Smart Fitness column.

Comments

Finally!   I feel validated!   For 25+ years my legs will start itching when I run or walk briskly.  Although it doesn't seem to happen on the eliptical machine at the gym (less jarring?)  One doctor said it's a histamine reaction and to take a Benedryl before going out.  
I've been saying that I was allergic to exercise for years.  Although I don't have serious symptoms, I would have red, watery eyes, sneezing fits, and a nose tickle for hours after a good cardio workout.
I take a Claritin each morning -- doc's recommendation -- and that stopped the hives I always used to get while running. Nice to know I'm not the only mutant.
This explains the hives I've gotten a few times after running...I think I'd eaten peanut butter right before, too. I just thought it was the detergent I had used or something, but maybe not! I guess I'll have to be more aware of it now, especially since it caused at least one death!
I've had this in the past, hives, vomiting, diarrhea, swollen eyes and lips, severe abdominal cramps, all brought on by running. I could never find a common trigger, eating, not eating, hot weather, cool weather; nothing besides simply going out for a run. The reactions coincidently subsided after I cleared up a long struggle with iron deficiency which I believe was caused by the existence of the h.pylori bacteria in my digestive system. Once I was rid of the h.pylori (after a round of antibiotics) iron levels increased and these strange and frightening reactions stopped.
I am afraid to work out vigorously because my face breaks out in a very painful rash.  I would rush home afterwards in tears and put cold washcloths on my face to help ease the pain.  I always used to joke that I was allergic to exercise/sweating, but it seems like I might actually be.  I wonder if a Benadryl after a workout would help...  I could workout at night and that way if I got drowsy it wouldn't be a bad thing.  I think I'll try it.
I would develop really bad hives when I would start to sweat while exercising.  After two ER visits, I was told that I had Exercise-Induced Anaphylaxis.  I carried a kit like you would use for bee stings.  Never had to give myself a shot, because Benadryl usually worked.  But I started to dread working out.  I never knew how bad it would get and it scared me!
Exercise-induced urticaria happened to me.  Ultimately my doctor and I figured out I was allergic to fosamax.  After I quit taking the drug and it dissipated from my system (took about 4 months) I never had the problem again.  I have maintained bone health using weights, eating healthily, and taking Citrical and Vitamin D3.
The only time I got my exercise induced hives was from my indoor, masters swim practices.  Those workouts were harder than any other I've ever done and the hives were everywhere; on my body, in my ears, on my scalp, and in my eyes.  Unfortunately, the only cure was to swim out of doors in an unheated pool, where I could better manage my core temperature.  However, it's important to note that swim workouts can make you as hot as a good long run.  
I've had it for years.  Though it nearly killed me a couple of times, it's managed by waiting a minimum of two hours before exercising and taking a Zyrtec. I also had it come on doing less stringent activities like lawn mowing.  If you're diagnosed with this, keep an Epipen in with you on long runs.  I keep on in my pocket all the time.
Starting in my mid 20's I would come down with hives covering my entire body, starting with my scalp and hands.  Exercise would cause it along with anything that raised my body temperature:  getting into a hot car, taking a hot shower.  One time I laughed too hard in a movie theater and it took 30 minutes for the intense itching & burning sensation to subside.  My doctors & allergists were not able to help me.  I finally found a wonderful doctor and together we systematically went down the list of different antihistamines.  I tried quite a few with no positive results until Zyrtec.  For me, it keeps the hives away and I'm thrilled to be able to exercise again (and laugh at funny movies!)  Thank you for your article!  Its the first one like it that I've come across.  This condition really affects a person's quality of life, so I'm glad you're providing information that can help other people.  
WOW!  I never would have thought it.  Everytime I walk briskly my upper legs and thighs itch like crazy!  So bad at times I have to actually stop and scratch them.  But then, the more I scratch, the more they itch.  It only happens from my knees up to my waistline on my legs.  So strange.  Like Jenny in St. Louis, I never have that problem on the eliptical either, and rarely when I run.  Only from a brisk walk or even moderate walk outdoors.  I'll try the Benedryl thing.
Wow! I am glad to see an article on this.  I actually have both exercise induces anaphlaxys and heat induces uticaria and they are not food allergy realated and when I tell people, they think it is the crazies thing they have ever heard.  My reactions started happening about 2 years ago but my Doctor told me there was a good chance that it will also go away.  Mine were so severe that I now have to take a EPI pin with me to the gym and the staff know where I keep it.  But luckily my daily antihistimene medicine, inhaler, and liquid benedryl keep it almost totally under control with the execption of a couple of small issues.  Glad to hear I'm not THAT weird...LOL.
Jenny, my wife has the same issue, she takes a Clariton an hour before and she's fine.
I've had this disease since my teens and after years of frustration and searching for a cure (not to mention feeling like a freak for being allergic to exercise), I got a new physician who recommended simply taking 10 mg of loratadine (generic Clairatin) several hours before exercising. it works! such a simple answer for a truly debilitating problem!
I've had this disease since my teens and after years of frustration and searching for a cure (not to mention feeling like a freak for being allergic to exercise), I got a new physician who recommended simply taking 10 mg of loratadine (generic Clairatin) several hours before exercising. it works! such a simple answer for a truly debilitating problem!
doctors are idiots.  they don't even ask what are your symptoms.  they just ask, whats wrong and give u medication.  not knowing your history or what you do, pills are there answer.
I am 32 years old, and I have suffered from cholinergic urticaria since I was 21. Whenever I exercise, I get this terrible hot flush, accompanied by uncontrollable itchiness that gets worse and worse until I just feel like I'm going to die. The only way to make it go away is to sit very still for a long time. Forget swimming...I can only do three laps before it begins. It's awful!!

It really puts a cramp in your lifestyle, espcially when you're used to being active, like I was. I went to four doctors over the years, but I wasn't diagnosed until a year ago! Unfortunately, nothing really helps keep the symptoms at bay. I've tried Claritin, Zyrtec (helped, but HMO says no way, no prescription), and Benadryl, which makes me sleepy. If anyone else has found ways to cope with this condition, please share!! It's tough to be a busy mom of three kids and have cholinergic urticaria.
I too consistently experience a skin reaction when participating in aerobic exercise. Red, splotchy, itchy whelps all over my legs-worse on upper portion. Irritating-YES, debilitating-NO. But, diphenhydramine (Benedryl) makes me sleepy and uncoordinated (not a good combo when on a treadmill) so I stick to other OTC non-drowsy antihistamines. Thanks for this article and for the assurance that I am not alone!!!
I've also read that if people - especially women - haven't worked out recently, the capillaries in their upper legs will itch and burn because they are not used to the rush of blood pumping through them.
Wow! I was diagnosed with exercised induced anaphylaxis 20 years ago. My face hands and feet would swell to double their normal size and my throat would swell almost completely shut. The the hives would appear. I had no idea I was dagerously close to death or that exercise was the trigger until I saw an allergist. I avoid eating at least 2 hours before exercising and keep benedryl handy but have not had an attack in years.
PS. I should have read the article before jumping in with my earlier comment...my food trigger is raw celery. I avoid it at all cost regardless of my exercise plans eventhough I did not test positive to celery during the allergy tests
I thought it was strange that every time I get on the elliptical or try running on the treadmill I throw up and can't walk. The stomach pain is unbearable and sometimes, I even pass out. Some people have told me I'm working out too hard, but really, I'm not working any harder than a typcial gym goer (I don't go to the gym anymore for these reasons). I do my own workouts and they seem to be doing great. I only do small amounts of exertion at a time and walk instead of run now. Now I know that there might be a reason behind my aversion to running.
When I was 17 and nervous about taking the S.A.T. the next morning, I went for a jog that night to try to relax. When I came back to my house, I was covered in pink/red hives. I thought it was related to anxiety over the test -- and, after reading this article, it seems that exercise may have also played a role. Maybe I did eat something before exercising -- I used to like to eat peanut butter on celery (a double-whammy according to the article) but it's been too many years to remember. But maybe now I know why I had hives that one time -- the only time in my life like that.
This has happened to me since I was a teenager and usually happened while jogging.  I had it happen once while dancing but my face swells and my entire body feels like my skin is on fire!  It starts in my hands and feet - they get a moddled look - then comes the pins and needles.  I will feel like i have something stuck in my throat and my tongue starts to itch and swell.  I usually know to jump off and exit the gym asap and get home and take two Benadryl.  It settles the symptoms after a few minutes but after that I am dizzy and lightheaded.  I always knew it was something to do with food and now I am careful not to eat four hours before strenuous activity and I have found that taking a prescription strength allergy medication everyday helps curb the attacks.  I have asked every single doctor that I could find about it and they had never heard of it.  I have a severe case...it can be embarassing and very scary when you are alone.  I usually make sure to tell the staff of whatever gym I'm in what my condition is and so if it happens and I can't get to my bag, they know I need the Benadryl.  I've been lucky thought to have caught it.  The only place I could find anything out about it was the internet on medical sites.  It's been crazy!  I am sorry you all suffer with this, too but I'm glad to know I'm not the only one!  I thought I had a birth defect.
I nearly died from an allergic reaction to exercise. The paramedics lost me twice on the way to the hospital. It came on without any prior warning. BTW, I have these without eating food.  It's the scariest thing ever. Have to talk myself down from the ledge each time I work out or break into a sweat.
i have to get light box therapy at least 3 days a week to control my itching.  it is also brought on my water, wind, sun, walking, sweating, stress- almost anything.  the lightbox, plus my pepcid and zyrtec and benedryl and one other med (the name escapes me) keeps my itching under control.  i take the meds daily.  i also use aveeno lotion and sometimes need the aveeno oatmeal bath.  ironically, i didn't itch in the south- only when i moved to the north.
YOU PEOPLE ARE LAZY!  ITS CALLED BEING OUT OF SHAPE!  Get out there & exercise more often & you will no longer feel sick.  
I don't have this condition but when I had hives from an allergic reaction to penicillin, I used Aerius when Benadryl made me too sleepy to stay awake during my University lectures.  Yo umight want to try that, it's non-drowsy.
While I don't have this particular condition, I do have exercise induced asthma. Can't run more than about 100 yard before breathing is actually painful. Unfortunately no medication helps. Hopefully they'll find a cure someday.
I remember breaking out in hives as early as 8 years old when I played soccer as a kid.  Everyone else shrugged it off as a minor grass allergy.  Since then I've gotten hives from fast-paced walking over a long period of time, running, or other forms of working out.  I got to a point where I stopped exercising in excess of 30min because it became so uncomfortable.  It's nice to finally know I'm not alone here!!
I call BS on this, the doc in the article even said it herself while beating around the bush like most docs do these days. ITS ALL FOOD ALLERGIES...just cause it doesnt do anything while sitting there doesnt mean its not a food allergy speed up digestion without exercise and i bet they have the same result. This is just gonna be another excuse for fat lazy people to say they cant work out. Give me a break, first we give kids that need a good back hand meds to slow their thinking, now we are giving fat people an excuse not to get off the couch give me a break. Someone fire this reporter!
Are you kidding me? Allergic to excercise? That literally means allergy to moving when you don't have to.
This is not about fat, lazy people. I run, lift, swim, bike more than most. I developed this allergy after college (where I played basketball)when I was 25. Before I was diagnosed with EIA I would consistently end up spending the night at the hospital with severe hives...usually after attending a wedding where I would eat then dance. Crazy. I thought I was allergic to marriage..should have rolled with that. Each time I would have a reaction it would be worse than the one before.  Ultimately, during one trip to the ER I stopped breathing. That was on Friday, I woke up Sunday in ICU on a respirator.  This is no joke. I was sent to an allergist. No food allergies at all.  Only after eating does this happen.  So, easy answer..don't eat and raise my heart rate within a three hour period. Not so good for hunger pains but I'd rather be hungry than dead. I carry an EPI pen and wear a bracelet. It's no joke and absolutely serious.
I was recently diagnosed with Allergy Induced Anaphylaxis.  I had a reaction on an Elliptical machine.  I had been taking aerobics classes for years & never had a problem.  First, my head started to itch, then I felt itchy all over my body & my forearms broke out in hives.  After exercising, I had trouble breathing.  I had no idea what was going on.  I've only had mild reactions since then, mostly hives, but no itching or breathing problems.  I think my body may have worked through it.  
I'm 46, and I've had chronic hives and severe asthma 24/7 most of my life. The family joke is being allergic to life. For me it is definitely genetic, and I have an ancestor who ended up in an insane asylum during the height of the initial use of electro- shock treatments, and another one who went through repeated exorcisms because of "The invisible bugs, crawling on their skin and in their bones."
On a good day it averages 4-5 with any excercize upping it to 8-9 on a scale of 1 to 10.
I also have a frightening array of known allergies: foods; chemicals; plants; medications (including most of the steroids and other things used to treat asthma & allergies, all antibiotics and most anesthesia); metals; soaps; perfumes; newspaper print; perspiration; recycled plastics; fluoride; chlorine... with more showing up yearly.
My allergic reactions include: more hives; massive swelling; excema; sunburn-like reddness and peeling; head-to-toe muscle and nerve spasms; migraines; and not breathing...
I currently have to take: Zertec; Benadryl;  Claritin; along with Theophylline; Albuterol (both inhaler and nebulizer) every two hours; Flexaril; Oxycodone; Asprin & Oxygen at night. I keep 3 Epi-Pens on hand, because 1 is rarely enough, and average use is 2 a month. I rinse off in a cool shower 8+ times a day and when the itching gets too bad I take a long soak in a tub with strong-brewed black tea & baking soda in the water.
I was allergic to both of my husbands, I have stopped breathing during sex, and have ended up in the hospital from skin contact with others because of medications, soaps, pollens among other things that they were either taking or had been in contact with... I have passed out, thrown up, gone into head-to-toe charley horse spasms scurrying through the plastics or soap sections of Walmart because I was in too much of a hurry to go around.
My style of excercize is a very slow focused blend (my own blend)of TaiChi and Exotic Dance with smooth flowing movement done to tribal/new age music in front of a fan & usually straight out of the shower...
I've had to learn to never allow myself to panic, because panic kills... that I can crawl through the house unable to breathe, and get to the nebulizer (I have 3 set up at all times), inhaler, epi-pen or ice cube tray in whichever order is the quickest. I've learned how to see the humor in my life, even when others can't.
And when I lay down at night or wake up in the morning and every inch itches, burns, tingles or charley horses, I remind myself to breathe and not to scratch.
Probaby the most significant things that allow me to get on with my life in spite of myself, or my circumstances, is that there is always something new to look forward to... a good book, a new song, a funny joke, the smile of friend, the giggle of my roomies' baby, my daughter's voice on the phone, my Mom and I itching together and finding it hilarious, the DEER that licked the back of my neck a few nights ago when I was having an asthma attack (I live in the country) in my back yard after a 108F day...
I continue to find new reasons to take a deep breath and enjoy being alive...    
WOW.  I am so glad to read this article.  In order to avoid the hives during a run I make sure that I don't eat within three hours of a workout.  I can always feel when it is starting and I makes sure to hop off the treadmill and leave the gym straight away.  The hives are really unattractive.
As for the folks who think it is an excuse not to work out, people don't really need an excuse not to work out.  If they don't want to they don't have to, simple as that.  But I love working out and so I continue to exercise but manage my workout and eating schedule more closely than my gym mates.  It is nice to know that I am not some oddity of nature. :-)    
 
And yes, I've just defined it. An allergy to excercise is too stupid to print. There may be several factors that decide why you get hives, tingling feeleings (muscles actually working), red in the face (kidding right?), and all other symptoms caused by excercise. I recently ran for the first time in over a decade, I'm 33 and used to run 2 miles in under 12 minutes with regularity. Last week hurt me for 4 days, I couldn't even walk without noticed displeasure. This is because my lazy butt hasn't done crap in a long time, imagine if I never ran before. My muscles were shocked and overworked for the condition they are in, but that's how you get them in condition. You have to punish the muscle and use it more rigorously to make it grow stronger. Have we all dismissed "no pain no gain". For those of you who claim to have been excercising for years and all of a sudden are now infected... I say see a shrink, you're either a hypochondriac (sp?)or just bs'ing.
Wow... Is that what that was??  It only happened to me once, but I was on the elliptical and had just eaten a light shrimp dinner and then while I was exercising broke out in huge hives all over.  I was panicked because had no idea what could have caused it. I'm not really allergic to anything usually.  Well, there it is!  Thanks for handing me the solution to that mystery.
I was thrilled to read this article as it describes me perfectly.  My allergy is to celery - and exactly as the article says, I can eat it and sit still- no problem. But if I go running after I've eaten celery (or celery seed spice), my face swells to the point that my own husband didn't recognize me as they wheeled me past him on a stretcher on my way into an ambulance b/c my throat was swelling closed! and the hives and itching is intense!

I am not fat, nor lazy and this has not stopped me form exercising. I just read lables now and carry an epi pen.
Cool!  After 20 years I finally I have an answer! I was a long distance runner in high school when this first happened to me.  For me it is greasy food.  I can't do any heavy exercise within about 6 hours of eating anything greasy, so needless to say I stay away from that stuff most of the time.  I have discovered though that if I have eaten something that would cause me problems and I still want to go on a run or play basketball I can take Benedryl ahead of time and be just fine.  I still run on a regular basis and have done 7 half marathons, so it is just a matter of watching what I eat!
By the way, for those of you who think this is a joke, just be glad you don't have it.  I was a long distance runner in high school and this first happned to me my freshman year.  After my first race in cross country I broke out in hives and had an asthma attack.  I never gave up running though, just figured out what to avoid eating before working out.  I ran a 4:40 mile and the 2 mile under 10 minutes, so I am certainly not a slacker.  I still run 10K and half marathons on a regular basis.  I just know what kind of foods are a problem and avoid them, or take some Benedryl before working out.
This is so strange. I do believe it though. There was a co-worker of mine that looked fine one day and when she exercised, not kidding, her face was all broken out. She told me she couldn't exercise for more than 40 minutes otherwise, breakouts would occur. She also had Rosecia. Maybe this is all true with no connections to allergies.
This is so strange. I do believe it though. There was a co-worker of mine that looked fine one day and when she exercised, not kidding, her face was all broken out. She told me she couldn't exercise for more than 40 minutes otherwise, breakouts would occur. She also had Rosecia. Maybe this is all true with no connections to allergies.
To those who don't believe that this actually happens you should consider yourself blessed rather than accusing sufferers of being fat and lazy.  I have been allergic to peanuts and shellfish since a child, however, I was not diagnosed with exercise induced asthma until in college.  It was a relief to finally hear the diagnosis from the doctor, to know that I was not just a slacker and there was a reason why I could not even run 50 yards without my lungs going into spasms.   This information may also explain the couple of hive episodes I have had over the years.  Thanks to all who shared.  Ignore the unbelievers.
Being on an elliptical machine may make you "nauseated", but it won't make you "nauseous".  Being nauseated means you feel sick; being nauseous means you make other people feel sick.
I am 29 years old, and when i take my annual physical training test, (pushup, situps, and my 2 mile run) I get serverly sick,(throwing up none stop for hours), I do not eat before taking the test, but i do drink gadorade, and plenty of water. I was told it was my blood pressure dropping to fast, and a deficiency with my white blood cells, but i think that it might be other factors, I am usually sick for 2 days afterwards, any advice if it might be the same thing that this article is explaining. or could it be the fact that it is this same thing.
I can't believe there are so many of us! Isn't it sad that we all thought we were imperfect snowflakes?

For a long time I abstained from all wheat products so I could run after work but last year I found that wasn't the culprit. No idea what causes mine, but it *seems* to be receding a bit with a concentrated effort to try a little bit of cardio each day, and each day I find I can go a little further before the symptoms roll in. It's really been hard to explain this to other people and they totally think I'm nuts.

Wouldn't it be great if we had some kind of a forum to compare notes? I *love* what exercise does for me when I can actually _do_ it; what a waste to be sidelined due to a silly allergy!

Why don't we have a hub somewhere on the Internet? Is there an EIA foundation I've not heard about? Anyone interested in getting organized? Any docs out there with suggestions?
Exercise induced asthma is nothing to laugh about. It actually holds you back from many teen and adult activities. You are a joke to anyone who hasn't seen you on the floor gasping for a breathe. I typically, see stars and pass out. Mall Walking, swimming, yoga, tai Chi and such are still available to us.
Those few comments by the ignorant people on stating people just make it up to get out of exercising need a hard slap to the face. I've been an athlete all my life, and was faced with this in my early 20s (after a hard run on the beach) and now 33 carry on Epi-Pen at all times.  It is very scary and the swelling happens so quickly you have barely enough time to call for help and/or take a an antihistamine.  Get off your high horse and do some research!  Do you think all those who have this condition want to be close to death and have to go to the ER just because "you" think we are hypocondriacs?  


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